Hydrochloric Acid → 4-(Piperidin-1-yl)butanoic acid hydrochloride

HRID 1029490ノート

反応式

HRID 1029490 の反応式
[ClH:1].CN1CCCC(C(O)=O)C1.[N:12]1([CH2:18][CH2:19][CH2:20][C:21]([O:23]CC)=[O:22])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.Cl>>[ClH:1].[N:12]1([CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 125147111-Methylpiperidine-3-carboxylic acid hydrochlorideHCID 14044356Ethyl 4-(piperidin-1-yl)butanoate

生成物 1

HCID 131720814-(Piperidin-1-yl)butanoic acid hydrochloride

実験手順

4-Piperidinobutyric acid hydrochloride may be obtained by working according to the method described in Example 4 for the preparation of 1-methyl-3-piperidinecarboxylic acid hydrochloride, but starting with ethyl 4-piperidinobutyrate (19.9 g) and 6N aqueous hydrochloric acid solution (66.5 cc), and by heating for 24 hours under reflux. 4-Piperidinobutyric acid hydrochloride (16.3 g), m.p. 190° C., is thereby obtained.

後処理

  1. temperatureby heating for 24 hours
  2. temperatureunder reflux

出典と根拠

ORDレコード
ord-1256304c21b642c9b4ca25f5069ae778
出典データセット
uspto-grants-1992_04
特許番号
US05102890

反応ノート

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