Hydrochloric Acid → 4-Diisopropylaminobutyric acid hydrochloride

HRID 1029499ノート

反応式

HRID 1029499 の反応式
[ClH:1].CN1CCCC(C(O)=O)C1.[CH:12]([N:15]([CH:24]([CH3:26])[CH3:25])[CH2:16][CH2:17][CH2:18][C:19]([O:21]CC)=[O:20])([CH3:14])[CH3:13].Cl>>[ClH:1].[CH:24]([N:15]([CH:12]([CH3:14])[CH3:13])[CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])([CH3:26])[CH3:25]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 125147111-Methylpiperidine-3-carboxylic acid hydrochlorideHCID 19900433Ethyl 4-diisopropylaminobutyrate

生成物 1

HCID 867456314-Diisopropylaminobutyric acid hydrochloride

実験手順

4-Diisopropylaminobutyric acid hydrochloride may be obtained by working according to the method described in Example 4 for the preparation of 1-methyl-3-piperidinecarboxylic acid hydrochloride, but starting with ethyl 4-diisopropylaminobutyrate (9.2 g) and 6 N aqueous hydrochloric acid solution (28.5 cc) and by heating for 6 hours under reflux. 4-Diisopropylaminobutyric acid hydrochloride (8 g), m.p. 136° C., is thereby obtained.

後処理

  1. temperatureby heating for 6 hours
  2. temperatureunder reflux

出典と根拠

ORDレコード
ord-b915410b6fbb47b2a8b507389b39408f
出典データセット
uspto-grants-1992_04
特許番号
US05102890

反応ノート

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