Ethylenediamine → 3-(Nitromethyl)-1,2-dihydronaphthalene

HRID 1029748ノート

反応式

HRID 1029748 の反応式
[CH2:1]1[C:10](=O)[CH2:9][C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2]1.C(N)CN.[N+:16]([CH3:19])([O-:18])=[O:17]>>[N+:16]([CH2:19][C:10]1[CH2:1][CH2:2][C:3]2[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=2)[CH:9]=1)([O-:18])=[O:17]

参加物

4

反応物 3

HCID 3301EthylenediamineHCID 6375NitromethaneHCID 682662-Tetralone

生成物 1

HCID 153234983-(Nitromethyl)-1,2-dihydronaphthalene

実験手順

A solution of β-tetralone (Aldrich Chemical Co., Milwaukee, Wis. 53233) (24.5 gm) and ethylenediamine (1.75 gm) in nitromethane (250 ml) was heated at 80° for 16 hours. The reaction mixture was filtered, and the filtrate was evaporated to give a red oil. This was partially purified by elution through a short silica column, eluting with hexane/EtOAc (9:1 v/v). The product was a pink oil (26 gm) which was not purified further but was taken directly for the next reaction.

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated
  3. customto give a red oil
  4. customThis was partially purified by elution through a short silica column
  5. washeluting with hexane/EtOAc (9:1 v/v)
  6. customwas not purified further
  7. customwas taken directly for the next reaction

出典と根拠

ORDレコード
ord-0120b895b96741fba3415c6e82c2f951
出典データセット
uspto-grants-1992_04
特許番号
US05102914

反応ノート

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