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1-(Thiophen-3-yl)ethanone → 3-Dimethylamino-1-thien-3-ylpropen-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Thiophen-3-yl)ethanone | HCID 15116 | — |
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 生成物 | 3-Dimethylamino-1-thien-3-ylpropen-1-one | HCID 596466 | 87% |
反応手順
A mixture of 48.4 g of 3-acetylthiophene and 75 ml of dimethylformamide dimethyl acetal, under nitrogen, is heated for 15 hours on a steam bath. The reaction is concentrated in vacuo and the residue crystallized from methylene chloride/hexane to give 60.55 g (87%) of the desired product, mp 89°-90° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05103015 |
| 出典データセット | uspto-grants-1992_04 |
| ORD ID | ord-fe6e3ea10657422eb07a3e6e988e0ae0 |
| 出典メモ | uspto-grants-1992_04 |