2-Ethoxyphenol → 2-Ethoxyphenoxysulfonyl isocyanate

HRID 1030006ノート

反応式

HRID 1030006 の反応式
Cl[S:2]([N:5]=[C:6]=[O:7])(=[O:4])=[O:3].[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[OH:17])[CH3:9]>C1(C)C(C)=CC=CC=1>[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[O:17][S:2]([N:5]=[C:6]=[O:7])(=[O:4])=[O:3])[CH3:9]

参加物

4

反応物 2

HCID 667552-EthoxyphenolHCID 70918Chlorosulfonyl isocyanate

生成物 1

HCID 190299582-Ethoxyphenoxysulfonyl isocyanate

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

反応条件

温度
140 °C

実験手順

67.9 g (0.48 mol) of chlorosulfonyl isocyanate are added dropwise at 25° C. to a solution of 55.2 g (0.4 mol) of 2-ethoxyphenol in 500 ml of xylene. When the dropwise addition is complete, the temperature is increased slowly to 140° C. and the mixture is refluxed for 2.5 hours. The mixture is cooled, and the solvent as well as excess chlorosulfonyl isocyanate are removed on a rotary evaporator. The yellow oil which remains (97.2 g=100% of theory) is employed without further purification.

後処理

  1. additionWhen the dropwise addition
  2. temperaturethe mixture is refluxed for 2.5 hours
  3. temperatureThe mixture is cooled
  4. customthe solvent as well as excess chlorosulfonyl isocyanate are removed on a rotary evaporator
  5. customis employed without further purification

出典と根拠

ORDレコード
ord-aec70c62939d41d5a380f35e73bc23fc
出典データセット
uspto-grants-1992_04
特許番号
US05104443

反応ノート

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