HCID 668793、化合物 → 4-hydroxy-N,N-dimethylbenzenesulfonamide
反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH3:14])[CH3:13])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[Cl-].[Al+3].[Cl-].[Cl-]>C1C=CC=CC=1>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH3:14])[CH3:13])(=[O:11])=[O:10])=[CH:5][CH:4]=1参加物
4
実験手順
A mixture of 4-methoxy-N,N-dimethylbenzenesulfonamide (37 g) and aluminum chloride (69 g) in benzene (170 ml) was stirred under reflux for 30 minutes. The reaction mixture was poured into ice-water and extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried over anhydrous magnesium sulfate, and concentrated. The residue was purified by recrystallization from toluene to give 4-hydroxy-N,N-dimethylbenzenesulfonamide (26 g).
後処理
- temperatureunder reflux for 30 minutes
- extractionextracted with ethyl acetate
- washThe combined organic layers were washed with water and brine
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated
- customThe residue was purified by recrystallization from toluene
出典と根拠
- ORDレコード
- ord-a7aa49b1789841658b301a6856c6a887
- 出典データセット
- uspto-grants-1992_04
- 特許番号
- US05104890
反応ノート
読み込み中…