ethyl N-cyanopropionimidate → HCID 178457586、化合物

HRID 1030218ノート

反応式

HRID 1030218 の反応式
[NH2:1][C@@H:2]1[C:7]2[CH:8]=[C:9]([C:12]#[N:13])[CH:10]=[CH:11][C:6]=2[O:5][C:4]([CH3:15])([CH3:14])[C@H:3]1[OH:16].[C:17]([N:19]=[C:20](OCC)[CH2:21][CH3:22])#[N:18]>C(O)C>[C:17]([N:19]=[C:20]([NH:1][C@@H:2]1[C:7]2[CH:8]=[C:9]([C:12]#[N:13])[CH:10]=[CH:11][C:6]=2[O:5][C:4]([CH3:14])([CH3:15])[C@H:3]1[OH:16])[CH2:21][CH3:22])#[N:18]

参加物

4

反応物 2

HCID 10820532ethyl N-cyanopropionimidateHCID 10943936(3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

生成物 1

HCID 178457586HCID 178457586、化合物収率 47%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of trans-4-amino-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1-benzopyran-6-carbonitrile (4.37 g) and ethyl N-cyanopropionimidate (2.65 g) in ethanol (22 ml) was refluxed for 10 hours. The mixture was cooled and concentrated under reduced pressure. The residue was pulverized with ethanol and recrystallized from ethanol to give trans-4-[N-[1-(cyanoimino)propyl]amino]-3,4-dihydro-2,2-dimethyl-3-hydroxy-2H-1-benzopyran-6-carbonitrile (2.81 g).

後処理

  1. temperaturewas refluxed for 10 hours
  2. temperatureThe mixture was cooled
  3. concentrationconcentrated under reduced pressure
  4. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-ef8b4c26a3324654b19cb9e0070fa59c
出典データセット
uspto-grants-1992_04
特許番号
US05104890

反応ノート

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