Methylamine → 1-(1,3-Benzoxazol-2-yl)-N-methylmethanamine
反応式
Cl[CH2:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[CH3:12][NH2:13]>O>[CH3:12][NH:13][CH2:2][C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1参加物
4
実験手順
2-(Chloromethyl)benzoxazole (3.99 g, 23.8 mmol) was dissolved in aqueous methylamine (40 mL, 40 wt % in H2O) at 10° C. under a nitrogen atmosphere. After 20 minutes, the reaction mixture was warmed to room temperature and stirred for 1 hour. The mixture was diluted with water and extracted with methylene chloride. The organic phase was dried (MgSO4) and concentrated to afford crude product which was purified by flash column chromatography (5% MeOH/CH2Cl2) to afford 3.18 g (82%) of pure product as a yellow oil.
後処理
- extractionextracted with methylene chloride
- dry with materialThe organic phase was dried (MgSO4)
- concentrationconcentrated
- customto afford crude product which
- customwas purified by flash column chromatography (5% MeOH/CH2Cl2)
出典と根拠
- ORDレコード
- ord-4d3a1ef2010e40fba525942b0186312d
- 出典データセット
- uspto-grants-1992_04
- 特許番号
- US05104892
反応ノート
読み込み中…