Hydrochloric Acid → alpha-{5-[4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]-2,4-dioxothiazolidin-3yl}acetic acid

HRID 1030387ノート

反応式

HRID 1030387 の反応式
[OH:1][C:2]1[C:3]([CH3:39])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH2:15][O:16][C:17]1[CH:38]=[CH:37][C:20]([CH2:21][CH:22]3[S:26][C:25](=[O:27])[N:24]([CH2:28][C:29]([O:31]C(C)(C)C)=[O:30])[C:23]3=[O:36])=[CH:19][CH:18]=1)([CH3:14])[CH2:6][CH2:5]2.Cl>O1CCOCC1>[OH:1][C:2]1[C:3]([CH3:39])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH2:15][O:16][C:17]1[CH:38]=[CH:37][C:20]([CH2:21][CH:22]3[S:26][C:25](=[O:27])[N:24]([CH2:28][C:29]([OH:31])=[O:30])[C:23]3=[O:36])=[CH:19][CH:18]=1)([CH3:14])[CH2:6][CH2:5]2

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 19822185t-Butyl alpha-{5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl]-2,4-dioxothiazolidin-3-yl}acetate

生成物 1

HCID 19822231alpha-{5-[4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl]-2,4-dioxothiazolidin-3yl}acetic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 1.0 g of t-butyl α-{5-[4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl ]-2,4-dioxothiazolidin-3-yl}acetate (prepared as described in Example 46) and 10 ml of a 4N dioxane solution of hydrogen chloride was allowed to stand at room temperature overnight. At the end of this time, the solvent was distilled off and the residue was washed with water to give the title compound as a pale yellow powder, softening at 85°-90° C.

後処理

  1. distillationAt the end of this time, the solvent was distilled off
  2. washthe residue was washed with water

出典と根拠

ORDレコード
ord-babe3a4713d34b24aeae93870948c4dc
出典データセット
uspto-grants-1992_04
特許番号
US05104888

反応ノート

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