反応式
[CH3:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:4][N:3]=1.[OH:13]O>C(O)(=O)C>[CH2:9]([O:8][C:6]([C:5]1[CH:11]=[CH:12][C:2]([CH3:1])=[N+:3]([O-:13])[CH:4]=1)=[O:7])[CH3:10]参加物
4
反応条件
- 温度
- 80 °C
実験手順
A mixture of 14.9 g of ethyl 6-methylnicotinate, 60 ml of acetic acid and 21.5 ml of 30% hydrogen peroxide was stirred at 80° C. for 16 hours, the reaction liquid was concentrated under a reduced pressure, water was added to the concentrate, and the mixture was extracted with chloroform. The chloroform layer was washed with an aqueous solution of potassium carbonate and dried over anhydrous potassium carbonate, and the solvent was removed under a reduced pressure to obtain 14.0 g of 5-ethoxycarbonyl-2-methyl pyridine-1-oxide. ##STR6##
後処理
- customthe reaction liquid
- concentrationwas concentrated under a reduced pressure, water
- additionwas added to the concentrate
- extractionthe mixture was extracted with chloroform
- washThe chloroform layer was washed with an aqueous solution of potassium carbonate
- dry with materialdried over anhydrous potassium carbonate
- customthe solvent was removed under a reduced pressure
出典と根拠
- ORDレコード
- ord-ee29a6252c3b4ec497a0dca1f09e593b
- 出典データセット
- uspto-grants-1992_04
- 特許番号
- US05106859
関連ノート
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