Acetic Anhydride → Ethyl 6-acetoxymethylnicotinate

HRID 1030511ノート

反応式

HRID 1030511 の反応式
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([CH3:13])=[N+:10]([O-])[CH:11]=1)=[O:5])[CH3:2].[C:14]([O:17]C(=O)C)(=[O:16])[CH3:15]>>[C:14]([O:17][CH2:13][C:9]1[CH:8]=[CH:7][C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:11][N:10]=1)(=[O:16])[CH3:15]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 15045502Ethyl 6-methyl-1-oxo-1lambda~5~-pyridine-3-carboxylate

生成物 1

HCID 15045503Ethyl 6-acetoxymethylnicotinate収率 59.2%

実験手順

A mixture of 13.7 g of 5-ethoxycarbonyl-2-methyl-pyridine-1-oxide and 15 g of acetic anhydride was stirred under reflux. Excess acetic anhydride was removed under a reduced pressure, and the residue was purified by distillation under a reduced pressure (110° C./0.1 mmHg) to obtain 10.0 g of ethyl 6-acetoxymethylnicotinate. ##STR7##

後処理

  1. temperatureunder reflux
  2. customExcess acetic anhydride was removed under a reduced pressure
  3. distillationthe residue was purified by distillation under a reduced pressure (110° C./0.1 mmHg)

出典と根拠

ORDレコード
ord-f82664c3b79d43438b9e0c0700f733fd
出典データセット
uspto-grants-1992_04
特許番号
US05106859

反応ノート

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