2'-Hydroxy-4',6'-bis(methoxymethoxy)-3'-(2-propenyl)acetophenone → 4-(Methoxymethoxy)benzaldehyde

HRID 1030723ノート

反応式

HRID 1030723 の反応式
O[C:2]1[C:7](CC=C)=[C:6]([O:11][CH2:12][O:13][CH3:14])[CH:5]=[C:4](OCOC)[C:3]=1[C:19](=[O:21])C>C(O)C>[CH3:14][O:13][CH2:12][O:11][C:6]1[CH:7]=[CH:2][C:3]([CH:19]=[O:21])=[CH:4][CH:5]=1

参加物

3

反応物 1

HCID 197448852'-Hydroxy-4',6'-bis(methoxymethoxy)-3'-(2-propenyl)acetophenone

生成物 1

HCID 2500744-(Methoxymethoxy)benzaldehyde収率 119.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In 40 ml of ethanol were dissolved 20.4 g of the 2'-hydroxy-4',6'-bis(methoxymethoxy)-3'-(2-propenyl)acetophenone obtained in Production Example 6 and 13.7 g of the p-methoxymethoxybenzaldehyde obtained in Production Example 23, and a 50% solution of potassium hydroxide in ethanol was added to the solution and the mixture was stirred at room temperature overnight to effect a reaction. After the reaction, the reaction mixture was neutralized with dilute hydrochloric acid and extracted with ethyl acetate, and the solvent was removed from the ethyl acetate layer by distillation. The obtained residue was crystallized from methanol to obtain 26.3 g (yield=85.9%) of 2'-hydroxy-4,4',6'-tris(methoxymethoxy)-3'-(2-propenyl)chalcone in the form of a yellow prism.

出典と根拠

ORDレコード
ord-e48f351ce1db4610bf295951ff9c8b26
出典データセット
uspto-grants-1992_04
特許番号
US05106871

反応ノート

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