2'-Hydroxy-4',6'-bis(methoxymethoxy)-3'-(3-methyl2-butenyl)acetophenone → 4-(Methoxymethoxy)-3-(3-methylbut-2-en-1-yl)benzaldehyde
反応式
O[C:2]1[C:7]([CH2:8][CH:9]=[C:10]([CH3:12])[CH3:11])=[C:6]([O:13][CH2:14][O:15][CH3:16])[CH:5]=[C:4](OCOC)[C:3]=1[C:21](=[O:23])C>C(O)C>[CH3:16][O:15][CH2:14][O:13][C:6]1[CH:5]=[CH:4][C:3]([CH:21]=[O:23])=[CH:2][C:7]=1[CH2:8][CH:9]=[C:10]([CH3:12])[CH3:11]参加物
実験手順
In 45 ml of ethanol were dissolved 6.99 g of the 2'-hydroxy-4',6'-bis(methoxymethoxy)-3'-(3-methyl2-butenyl)acetophenone obtained in Production Example 13 and 5.01 of the 4-methoxymethoxy-3-(3-methyl-2-butenyl)benzaldehyde, and the solution was cooled to 0° C. Then, 65 ml of a saturated solution of potassium hydroxide in ethanol was added to the solution and the mixture was stirred at room temperature overnight. The reaction liquid was neutralized with 6N hydrochloric acid and extracted with ethyl acetate, and the ethyl acetate layer was washed with water, dried with anhydrous sodium sulfate and filtered. The solvent was removed from the filtrate by distillation and the residue was recrystallized from n-hexane to obtain 7.22 g (yield=61.7%) of 2'-hydroxy-4,4',6'-tris(methoxymethoxy)-3,3'-bis(3-methyl-2-butenyl)chalcone.
出典と根拠
- ORDレコード
- ord-4dba58bd42d3462d8a7eec80dc55772c
- 出典データセット
- uspto-grants-1992_04
- 特許番号
- US05106871
反応ノート
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