Hydrochloric Acid → 2-(Isobutylamino)benzyl chloride hydrochloride

HRID 1030798

反応式

HRID 1030798 の反応式
[CH2:1]([NH:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH2:8]O)[CH:2]([CH3:4])[CH3:3].[ClH:14]>>[ClH:14].[CH2:1]([NH:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH2:8][Cl:14])[CH:2]([CH3:4])[CH3:3]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 10130218Benzenemethanol, 2-[(2-methylpropyl)amino]-

生成物 1

HCID 148394362-(Isobutylamino)benzyl chloride hydrochloride収率 68%

反応条件

温度
100 °C

実験手順

In 190 ml of conc. hydrochloric acid was dissolved 19.1 g of 2-(isobutylamino)benzyl alcohol, and the solution was heated in a sealed tube at 100° C. for 40 min. The reaction mixture was stirred for 30 min. under chilling with ice and the precipitated crystals were collected by filtration. The collected crystals were washed successively with hydrochloric acid and acetone and dried to give 16.9 g (yield: 68%) of 2-(isobutylamino)benzyl chloride hydrochloride as a white crystalline product.

後処理

  1. temperatureunder chilling with ice
  2. filtrationthe precipitated crystals were collected by filtration
  3. washThe collected crystals were washed successively with hydrochloric acid and acetone
  4. customdried

出典と根拠

ORDレコード
ord-d7d07fa9f7ad4a61a7f7e61ebfa84079
出典データセット
uspto-grants-1992_04
特許番号
US05106976

関連ノート

読み込み中…