Butyl bromide → 2,3-Dichloro-4-methoxy-N-n-butylaniline

HRID 1031137

反応式

HRID 1031137 の反応式
[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([O:10][CH3:11])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH2:12](Br)[CH2:13][CH2:14][CH3:15].C(=O)([O-])O.[Na+]>COCCO>[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([O:10][CH3:11])[CH:6]=[CH:5][C:3]=1[NH:4][CH2:12][CH2:13][CH2:14][CH3:15]

参加物

5

反応物 3

HCID 8002Butyl bromideHCID 516892Sodium BicarbonateHCID 136906392,3-Dichloro-4-methoxyaniline

生成物 1

HCID 136884512,3-Dichloro-4-methoxy-N-n-butylaniline

試薬・触媒・溶媒 1

HCID 80192-Methoxyethanol溶媒

実験手順

A mixture of 2,3-dichloro-4-methoxyaniline (19.2 g), n-butylbromide (22.0 g), sodium hydrogen carbonate (40 g) and methylcellosolve (350 ml) is stirred at 95°-100° C. for about 48 hours. The cooled mixture is filtered, and the filtrate is evaporated in vacuo. The remaining material is washed with water and is thereafter recrystallized from ethanol to give the title compound with a melting point of 47°-49° C.

後処理

  1. filtrationThe cooled mixture is filtered
  2. customthe filtrate is evaporated in vacuo
  3. washThe remaining material is washed with water
  4. customis thereafter recrystallized from ethanol

出典と根拠

ORDレコード
ord-e3504bd97ea84bcfa34630b861623f7f
出典データセット
uspto-grants-1992_04
特許番号
US05109009

関連ノート

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