化工社化工社 化学情報印刷レポート · 研究参考用
Tert-Butyl hypochlorite → 2-Amino-5-chloro-4-fluorobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tert-Butyl hypochlorite | HCID 521297 | — |
| 反応物 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Amino-5-chloro-4-fluorobenzoic acid | HCID 21979255 | 111.2% |
反応手順
To a solution of 4-fluoroanthranilic acid (0.882 g, 5.69 mmol) in methylene chloride (50 ML) and acetic acid (10 mL) is added tert-butyl hypochlorite (0.71 mL, 6.25 mmol) solution in dichloromethane (1 mL) dropwise over 1 minute. After 90 minutes, the reaction mixture is washed with water and brine. The organic layer is dried over MgSO4, filtered, and the filtrate concentrated to afford 5-chloro-4-fluoroanthranilic acid (1.20 g). MS CI: m/e 188 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094780B1 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-fa7df086e4e6499c96d448bcfa269c2e |
| 出典メモ | uspto-grants-2006_08 |