HCID 14422913、化合物 → 1-Cyclopropyl-6,8-difluoro-7-methyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
反応式
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:19])=[C:11]([CH2:15]C(O)=O)[C:12]=3[F:14])[C:7](=[O:20])[C:6]([C:21]([OH:23])=[O:22])=[CH:5]2)[CH2:3][CH2:2]1>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:19])=[C:11]([CH3:15])[C:12]=3[F:14])[C:7](=[O:20])[C:6]([C:21]([OH:23])=[O:22])=[CH:5]2)[CH2:2][CH2:3]1参加物
3
実験手順
0.5 g of the compound from Example 11 is heated to 240° C. for one hour in 5 ml of diphenyl ether. The residue remaining after distilling off the solvent consists of 0.3 g of crude product of melting point 208°-10° C. Recrystallization from ethanol gives a melting point of 226°-28°.
後処理
- distillationafter distilling off the solvent
- customRecrystallization from ethanol
- customgives a melting point of 226°-28°
出典と根拠
- ORDレコード
- ord-1d37e95ba85d4073845ff7bcabf66e34
- 出典データセット
- uspto-grants-1990_09
- 特許番号
- US04956465
反応ノート
読み込み中…