Methanol → Anecortave

関与物質

反応手順

At room temperature, 1.5 g of 21-acetoxy-17-hydroxy-4,9(11)-pregnadiene-3,20-dione in 40 ml is agitated for 2 hours at room temperature with 15 ml of methanol 0.2N methanolic potassium hydroxide solution. The reaction mixture is introduced into ice water. The precipitated product is suctioned off, dissolved in methylene chloride, washed with water, and dried over sodium sulfate, thus obtaining 1.2 g of 17,21-dihydroxy-4,9(11) pregnadiene3,20-dione; mp 248.2° C.

情報源と証拠