化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Ethyl p-chlorobenzalpyruvate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-(4-Chlorophenyl)-2-oxobut-3-enoic acid | HCID 367457 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ethyl p-chlorobenzalpyruvate | HCID 54351366 | 99% |
反応手順
To the p-chlorobenzalpyruvic acid from step A in wet ethyl acetate was added triethylamine (11.1 g, 0.11 moL) at a rate less than 0.5 mL/min followed by azeotropic removal of water. Ethyl chloroformate (11.9 g, 0.11 moL) was then added at room temperature over a one hour period and the batch aged one hour to effect complete reaction. Workup followed, as in Example 1, to afford ethyl p-chlorobenzalpyruvate in 99% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04956490 |
| 出典データセット | uspto-grants-1990_09 |
| ORD ID | ord-175cd20443e9451c9c4ef28cd610ad24 |
| 出典メモ | uspto-grants-1990_09 |