Water → HCID 10752540、化合物

HRID 1032251ノート

反応式

HRID 1032251 の反応式
O[CH:2]([C:13]1[O:14][CH:15]=[CH:16][CH:17]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10].[OH2:18]>P(=O)(O)(O)O.P([O-])([O-])(O)=O.[K+].[K+]>[OH:14][CH:15]1[CH:16]=[CH:17][C:13](=[O:18])[CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10]

参加物

4

反応物 2

HCID 962WaterHCID 10728746HCID 10728746、化合物

生成物 1

HCID 10752540HCID 10752540、化合物収率 80.7%

試薬・触媒・溶媒 1

HCID 22644153HCID 22644153、化合物触媒

実験手順

Into a four necked-flask equipped with a stirrer and a thermometer, 2-(1-hydroxy-7-methoxycarbonylheptyl)-furan 114 g), water (4560 g) and potassium monohydrogen phosphate-phosphoric acid buffer (3.8 g) were charged, and the resulting mixture (pH 4.2) was stirred at 100° C. under nitrogen stream until the starting compound was consumed perfectly. The reaction mixture was cooled and extracted with methylisobutylketone (600 ml) two times. The extracts were combined together and concentrated under reduced pressure to give a mixture (92 g) of 3-hydroxy-2-(6-methoxycarbonylhexyl)-4-cyclopentenone and 4-hydroxy-2-(6-methoxycarbonylhexyl)-2-cyclopentenone. Yield, 80.7%.

後処理

  1. customInto a four necked-flask equipped with a stirrer
  2. customwas consumed perfectly
  3. temperatureThe reaction mixture was cooled
  4. extractionextracted with methylisobutylketone (600 ml) two times
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-96de01cd7656405ca2128f25403a97c5
出典データセット
uspto-grants-1990_09
特許番号
US04957867

反応ノート

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