Acetyl chloride → N-Dodecylacetamide

HRID 1032282ノート

反応式

HRID 1032282 の反応式
[CH2:1]([NH2:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(N(CC)CC)C.[C:21](Cl)(=[O:23])[CH3:22]>ClCCl>[C:21]([NH:13][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])(=[O:23])[CH3:22]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 13583Dodecylamine

生成物 1

HCID 19764N-Dodecylacetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 1-dodecylamine (1.049 g, 5.59 mmol), triethylamine (0.86 ml, 6.15 mmol) and acetyl chloride (0.44 ml, 6.15 mmol) in dichloromethane (10 ml) was stirred at room temperature for 3h. The mixture was quenched with water and the organic phase was separated. Evaporation of the dried (magnesium sulfate) organic phase gave a solid, which was recrystallized from hexane to give the titled amide.

後処理

  1. customThe mixture was quenched with water
  2. customthe organic phase was separated
  3. customEvaporation of the
  4. dry with materialdried (magnesium sulfate) organic phase
  5. customgave a solid, which
  6. customwas recrystallized from hexane

出典と根拠

ORDレコード
ord-1c95227a49a044f4a215eed2c8de5bdb
出典データセット
uspto-grants-1990_09
特許番号
US04957917

反応ノート

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