化工社化工社 化学情報印刷レポート · 研究参考用
Benzoyl Peroxide → 2-(Bromomethyl)-5-chlorobenzo[d]oxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl Peroxide | HCID 7187 | — |
| 反応物 | 5-Chloro-2-methylbenzoxazole | HCID 29510 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 2-(Bromomethyl)-5-chlorobenzo[d]oxazole | HCID 12745945 | — |
反応手順
A solution of the benzoxazole (1.3 g) (Step 2) in CCl4 (15 mL) was treated with N-bromo-succinimide (NBS) (1.5 g) and benzoyl peroxide (38 mg) at reflux using a U.V. lamp for 24 hours. Filtration, evaporation, and flash chromatography of the residue using 1:1 hexane/toluene afforded the title compound which was used as such for the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04957932 |
| 出典データセット | uspto-grants-1990_09 |
| ORD ID | ord-c8a92444ed334775971a2479e214d719 |
| 出典メモ | uspto-grants-1990_09 |