HCID 13629298、化合物 → 2-(3-Amino-4-benzyloxyphenyl)acetic acid dipropylamide

HRID 1032509ノート

反応式

HRID 1032509 の反応式
[CH2:1]([N:4]([CH2:25][CH2:26][CH3:27])[C:5](=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:9]([N+:21]([O-])=O)[CH:8]=1)[CH2:2][CH3:3].[H][H]>[Ni].CO>[CH2:25]([N:4]([CH2:1][CH2:2][CH3:3])[C:5](=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:9]([NH2:21])[CH:8]=1)[CH2:26][CH3:27]

参加物

5

反応物 2

HCID 13629298HCID 13629298、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 136292992-(3-Amino-4-benzyloxyphenyl)acetic acid dipropylamide収率 73.7%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

In the presence of Raney nickel, 36.0 g of 2-(4-benzyloxy-3-nitrophenyl)acetic acid dipropylamide is hydrogenated in 600 ml of methanol until 6.7 l of hydrogen has been absorbed, which takes about 4.5 hours. The crude product obtained after removing the catalyst by filtration and after evaporation is chromatographed on silica gel with cyclohexane/ethyl acetate (1:1), thus obtaining 24.4 g of pure 2-(3-amino-4-benzyloxyphenyl)acetic acid dipropylamide as an oil.

後処理

  1. customhas been absorbed
  2. customThe crude product obtained
  3. customafter removing the catalyst
  4. filtrationby filtration
  5. customafter evaporation
  6. customis chromatographed on silica gel with cyclohexane/ethyl acetate (1:1)

出典と根拠

ORDレコード
ord-738ee511f8344515839a0616d119ba45
出典データセット
uspto-grants-1990_09
特許番号
US04958026

反応ノート

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