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Hydrochloric Acid → (4-(Benzyloxy)-3-nitrophenyl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 4-(Benzyloxy)-3-nitrobenzaldehyde | HCID 7023554 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (4-(Benzyloxy)-3-nitrophenyl)methanol | HCID 13629301 | 79.8% |
反応手順
Under ice cooling, 75.7 g of sodium borohydride is introduced within one hour into 128.0 g of 4-benzyloxy-3-nitrobenzaldehyde in 4.2 l of methanol. After 1.5 hours of agitation at room temperature, 1.1 l of 2N HCl is added dropwise. The isolated reaction product is recrystallized from a mixture of 680 ml of diisopropyl ether and 170 ml of isopropanol, thus obtaining 103.0 g of 4-benzyloxy-3-nitrobenzyl alcohol, mp 76°-77° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04958026 |
| 出典データセット | uspto-grants-1990_09 |
| ORD ID | ord-332bfc4ec5674ccebc0f9df332c27bfd |
| 出典メモ | uspto-grants-1990_09 |