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Thionyl Chloride → 4-Benzyloxy-3-nitrobenzyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (4-(Benzyloxy)-3-nitrophenyl)methanol | HCID 13629301 | — |
| 生成物 | 4-Benzyloxy-3-nitrobenzyl chloride | HCID 13629302 | — |
反応手順
Under agitation, 58.3 g of 4-benzyloxy-3-nitrobenzyl alcohol is introduced in incremental portions into 250 ml of thionyl chloride, stirred for 30 minutes at room temperature, and concentrated under vacuum. The residue is recrystallized from diisopropyl ether while decolorizing with active carbon, thus producing 50.9 g of 4-benzyloxy-3-nitrobenzyl chloride, mp 60°-61° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04958026 |
| 出典データセット | uspto-grants-1990_09 |
| ORD ID | ord-f154fe0b6dc34555ac16b885a6de168a |
| 出典メモ | uspto-grants-1990_09 |