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1-(3-Benzyloxy-4-nitrophenyl)-2-dimethylaminoethene → (3-Benzyloxy-4-nitrophenyl)acetonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Benzyloxy-4-nitrophenyl)-2-dimethylaminoethene | HCID 54049086 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (3-Benzyloxy-4-nitrophenyl)acetonitrile | HCID 13629306 | 45.8% |
反応手順
18.7 g of N-[2-(3-benzyloxy-4-nitrophenyl)ethenyl]-N,N-dimethylamine and 21.3 g of hydroxylamineorthosulfonic acid in 420 ml of water are stirred for 3 days at room temperature. The thus-separated solid product is chromatographed on silica gel with cyclohexane/acetic acid (1:1), thus obtaining 7.7 g of (3-benzyloxy-4-nitrophenyl)acetonitrile, mp 73°-85° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04958026 |
| 出典データセット | uspto-grants-1990_09 |
| ORD ID | ord-22bb6ba83c244b488df30ab3579dde84 |
| 出典メモ | uspto-grants-1990_09 |