Potassium Carbonate → 4-(2-Chloroethoxy)benzamide
反応式
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.C1(S(O[CH2:21][CH2:22][Cl:23])(=O)=O)C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Cl:23][CH2:22][CH2:21][O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1参加物
5
実験手順
A mixture of 4-hydroxybenzamide (194 g, 1.25M), 2-(benzenesulphonyloxy)ethyl chloride (359 g, 1.8M), and potassium carbonate (172.8 g, 1.25M) in butan-2-one (2.16 1) was stirred at reflux for 24 hours. After cooling, distilled water (2.0 1) was added and the resultant precipitate filtered off, washed with water, and dried. Crystallisation from ethanol gave the title compound, yield (232.0 g), m.p. 66°.
後処理
- temperatureat reflux for 24 hours
- temperatureAfter cooling
- distillationdistilled water (2.0 1)
- additionwas added
- filtrationthe resultant precipitate filtered off
- washwashed with water
- customdried
- customCrystallisation from ethanol
出典と根拠
- ORDレコード
- ord-5a6182fcaddf40e0a3bba976ba19cbe9
- 出典データセット
- uspto-grants-1990_09
- 特許番号
- US04959366
反応ノート
読み込み中…