2-Methoxy-3-hydroxymethyl-5-ethyl-6-methylpyridine → 2-Methoxy-5-ethyl-6-methylnicotinaldehyde
反応式
[CH3:1][O:2][C:3]1[C:8]([CH2:9][OH:10])=[CH:7][C:6]([CH2:11][CH3:12])=[C:5]([CH3:13])[N:4]=1>C1C=CC=CC=1.[O-2].[O-2].[Mn+4]>[CH3:1][O:2][C:3]1[N:4]=[C:5]([CH3:13])[C:6]([CH2:11][CH3:12])=[CH:7][C:8]=1[CH:9]=[O:10]参加物
4
実験手順
Activated manganese dioxide (2.0 g) was added to a solution of 2-methoxy-3-hydroxymethyl-5-ethyl-6-methylpyridine (1.18 g, 6.5 mmol) in dry benzene (20 mL) and refluxed 5-10 hours. The warm suspension was filtered through a pad of anhydrous Na2SO4 and evaporated to yield 1.05 g (90%) of a viscous oil which solidified.
後処理
- temperaturerefluxed 5-10 hours
- filtrationThe warm suspension was filtered through a pad of anhydrous Na2SO4
- customevaporated
出典と根拠
- ORDレコード
- ord-97e0369315354bf597ed57db75aa3afc
- 出典データセット
- uspto-grants-1994_05
- 特許番号
- US05308854
反応ノート
読み込み中…