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Potassium Carbonate → Diethyl 1-hexyl-2,5-dioxo-4-imidazolylphosphonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Iodohexane | HCID 12527 | — |
| 反応物 | Diethyl (2,5-dioxo-2,5-dihydro-1H-imidazol-4-yl)phosphonate | HCID 53733419 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Diethyl 1-hexyl-2,5-dioxo-4-imidazolylphosphonate | HCID 53646860 | — |
反応手順
To a solution of diethyl 2,5-dioxo-4-imidazolylphosphonate (6.00 g, 0.025 moles) in DMF (15 mL), under N2, is added K2CO3 (17.5 g, 0.127 moles) and 1-iodohexane (3.75 mL, 0.025 moles). This mixture is stirred at room temperature for 16 hours. The mixture is diluted with ether (300 mL) and washed with water and brine and then dried over MgSO4. Evaporation of solvents under high vacuum affords the required product as a viscous yellow oil. (Mass spectrometry also revealed a small amount of diethyl 1,3-dihexyl-2,5-dioxo-4-imidazolylphosphonate).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05308853 |
| 出典データセット | uspto-grants-1994_05 |
| ORD ID | ord-e171d2619a6f4e12831c6f542031fa3d |
| 出典メモ | uspto-grants-1994_05 |