Catechol → 2-Ethyl-2-methyl-1,3-benzodioxole

HRID 1033169ノート

反応式

HRID 1033169 の反応式
[C:1]1([C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4])[OH:2].[CH3:9][C:10](=O)[CH2:11][CH3:12].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>C(Cl)Cl>[CH2:10]([C:11]1([CH3:12])[O:4][C:3]2[CH:5]=[CH:6][CH:7]=[CH:8][C:1]=2[O:2]1)[CH3:9]

参加物

5

反応物 3

HCID 289CatecholHCID 6569Methyl Ethyl KetoneHCID 14812Phosphorus oxide (P4O10)

生成物 1

HCID 126081602-Ethyl-2-methyl-1,3-benzodioxole

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Following Intermediate Method 3, the reaction of catechol with 2-butanone and phosphorus pentoxide in methylene chloride produces 2-ethyl-2-methyl-1,3-benzodioxole, (XVI). Nitration of (XVI) with nitric and sulfuric acid in methylene chloride yields 2-ethyl-2-methyl-5-nitro-1,3-benzodioxole, (XVII). Subsequent hydrogenation of the compound (XVII) with platinum oxide in ethanol produces 5-amino-2-ethyl-2-methyl-1,3-benzodioxole, (XVIII). ##STR30##

出典と根拠

ORDレコード
ord-d4a2c283957342f69698cc36c704c909
出典データセット
uspto-grants-1994_05
特許番号
US05310724

反応ノート

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