Methyl Thioglycolate → 2-Chloro-4-fluoro-5-nitrothiobenzoic acid (methoxycarbonylmethyl) ester

HRID 1033214ノート

反応式

HRID 1033214 の反応式
ClC1C(C([CH2:10][C:11]([O:13][CH3:14])=[O:12])=S)=CC(N=C2N3N(CCCC3)C(=O)S2)=C(F)C=1.[Cl:27][C:28]1[CH:36]=[C:35]([F:37])[C:34]([N+:38]([O-:40])=[O:39])=[CH:33][C:29]=1[C:30](Cl)=[O:31].COC(=O)C[SH:45]>C(OCC)(=O)C>[CH3:14][O:13][C:11]([CH2:10][O:31][C:30](=[S:45])[C:29]1[CH:33]=[C:34]([N+:38]([O-:40])=[O:39])[C:35]([F:37])=[CH:36][C:28]=1[Cl:27])=[O:12]

参加物

5

反応物 3

HCID 16907Methyl ThioglycolateHCID 151243842-Chloro-4-fluoro-5-nitrobenzoyl chlorideHCID 542425799-[4-Chloro-2-fluoro-5-(methoxycarbonylmethylthiocarbonyl)-phenylimino]-8-thia-1,6-diazabicyclo[4.3.0]nonan-7-one

生成物 1

HCID 540569242-Chloro-4-fluoro-5-nitrothiobenzoic acid (methoxycarbonylmethyl) ester

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

The preparation of 9-[4-chloro-2-fluoro-5-(methoxycarbonylmethylthiocarbonyl)-phenylimino]-8-thia-1,6-diazabicyclo[4.3.0]nonan-7-one is given by way of example: ##STR22## 48 g of 2-chloro-4-fluoro-5-nitrobenzoic acid chloride are added dropwise, with stirring, at room temperature to a solution of 20 ml of thioglycolic acid methyl ester in 100 ml of ethyl acetate. The batch is stirred for 18 hours and then the solvent is evaporated off in vacuo to yield 19 g of 2-chloro-4-fluoro-5-nitrothiobenzoic acid (methoxycarbonylmethyl) ester in the form of an oil having nD23 : 1.5709.

後処理

  1. customthe solvent is evaporated off in vacuo

出典と根拠

ORDレコード
ord-1d7d8caf462e4bab92a4806ab67409e8
出典データセット
uspto-grants-1994_05
特許番号
US05310722

反応ノート

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