HCID 86747828、化合物 → (cis) 3,3,5-Trimethylcyclohexyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropionate

HRID 1033231ノート

反応式

HRID 1033231 の反応式
[Cl:1][C:2]1[CH:34]=[CH:33][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:32]=[CH:31][C:14]([O:15][C:16]([CH3:30])([CH3:29])[C:17]([O:19][C@H:20]3[CH2:25][C@H:24]([CH3:26])[CH2:23][C:22]([CH3:28])([CH3:27])[CH2:21]3)=[O:18])=[CH:13][CH:12]=2)=[O:7])=[CH:4][CH:3]=1>[K+].[Br-]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:9][CH2:10][C:11]2[CH:32]=[CH:31][C:14]([O:15][C:16]([CH3:29])([CH3:30])[C:17]([O:19][C@H:20]3[CH2:25][C@@H:24]([CH3:26])[CH2:23][C:22]([CH3:27])([CH3:28])[CH2:21]3)=[O:18])=[CH:13][CH:12]=2)=[O:7])=[CH:33][CH:34]=1

参加物

3

反応物 1

HCID 86747828HCID 86747828、化合物

生成物 1

HCID 86747829(cis) 3,3,5-Trimethylcyclohexyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropionate

試薬・触媒・溶媒 1

HCID 253877Potassium Bromide溶媒

実験手順

The reaction is carried out under the same conditions as in Example 3 and with the same proportions of reactants. After chromatography on a silica column, the product can be recrystallized from ethyl acetate to give the title derivative in the form of white crystals melting at 122° C. (capillary). Thin layer chromatography under the conditions already described shows a single spot whose Rf of 0.2 is identical to that of the product of Example 3. The IR spectrum run in KBr has the same principal characteristic bands as in Example 3, although the fine bands between 1000 and 600 cm-1 are markedly different.

出典と根拠

ORDレコード
ord-ddeb70bed69946b6aa1b9548c4483e62
出典データセット
uspto-grants-1994_05
特許番号
US05310757

反応ノート

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