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HRID 1033338作成日：2026年10月26日

Sodium borohydride → (2R*,4S*)-2-benzyl-1-(3,5-dihydroxybenzoyl)-N-(4-quinolylmethyl)-4-piperidinamine

https://huagongshe.com/reaction/1033338

反応式

関与物質

役割名称HCID仕込み量
反応物Sodium borohydrideHCID 4311764—
反応物(2R*,4S*)-2-benzyl-1-(3,5-dihydroxybenzoyl)-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamineHCID 56976894—
生成物(2R*,4S*)-2-benzyl-1-(3,5-dihydroxybenzoyl)-N-(4-quinolylmethyl)-4-piperidinamineHCID 44288795—

反応手順

0.097 g (0.172 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dihydroxybenzoyl)-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine is reacted with 0.026 g (0.688 mmol) of sodium borohydride in analogy to Example 2. The title compound ##STR73## is obtained (0.023 g, 29%) as white foam. TLC: methylene chloride/methanol/conc. ammonia (350:50:1) Rf =0.57, FD-MS: M+ =467.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05310743
出典データセットuspto-grants-1994_05
ORD IDord-8a07f8d894ca403986255be45f8bfa22
出典メモuspto-grants-1994_05