3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide → 3-[[1-[[2'-nitrophenoxy-[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]amino]-1,1-dimethyl-3-oxopropylcarbamic acid, 1,1-dimethyethyl ester

HRID 1033429

反応式

HRID 1033429 の反応式
BrCCC1C=CC([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)=CC=1.[C:26]([O:30][C:31]([NH:33][C:34]([CH3:52])([CH3:51])[CH2:35][C:36]([NH:38][C@@H:39]1[CH2:45][CH2:44][C:43]2[CH:46]=[CH:47][CH:48]=[CH:49][C:42]=2[NH:41][C:40]1=[O:50])=[O:37])=[O:32])([CH3:29])([CH3:28])[CH3:27]>>[N+:23]([C:20]1[CH:19]=[CH:22][CH:17]=[CH:18][C:21]=1[C:22]1[CH:15]=[CH:10][C:11]([CH2:12][N:41]2[C:42]3[CH:49]=[CH:48][CH:47]=[CH:46][C:43]=3[CH2:44][CH2:45][C@@H:39]([NH:38][C:36](=[O:37])[CH2:35][C:34]([NH:33][C:31](=[O:32])[O:30][C:26]([CH3:29])([CH3:27])[CH3:28])([CH3:52])[CH3:51])[C:40]2=[O:50])=[CH:18][C:17]=1[O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:10]=1)([O-:25])=[O:24]

参加物

3

反応物 2

HCID 104746043-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamideHCID 541412174'-Bromoethyl-2-(4-nitrophenoxy)-1,1'-biphenyl

生成物 1

HCID 1317184023-[[1-[[2'-nitrophenoxy-[1,1'-biphenyl]-4-yl]methyl]-2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]amino]-1,1-dimethyl-3-oxopropylcarbamic acid, 1,1-dimethyethyl ester

実験手順

Prepared from 4'-bromoethyl-2-(4-nitrophenoxy) -1,1'-biphenyl and 3-t-butoxycarbonylamino-3-methyl -N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-(R) -yl]-butanamide (Example 57, Step A) by the procedure described in Example 69, Step D. 1NMR (200 MHz, CDCl3): 1.32 (s,6H), 1.38 (s,9H), 1.78 (m,1H), 2.3-2.7 (m,5H), 4.47 (m,1H), 4.75 (d,15 Hz,1H), 5.13 (d,15 Hz,1H), 6.63 (d,7 Hz,1H), 6.75 (d,8 Hz,2H), 7.05-7.50 (m,/11H), 7.97 (s,1H), 7.98 (d,8 Hz,2H).

出典と根拠

ORDレコード
ord-a730f94af2f147009082b756213500c8
出典データセット
uspto-grants-1994_05
特許番号
US05310737

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