3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide → HCID 19766191、化合物

HRID 1033449

反応式

HRID 1033449 の反応式
[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:30])([CH3:29])[CH2:13][C:14]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=2[NH:19][C:18]1=[O:28])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:32][C:33]1[CH:38]=[CH:37][C:36]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=2[C:45]([F:48])([F:47])[F:46])=[CH:35][CH:34]=1>>[CH2:1]([O:8][C:9]([NH:11][C:12]([CH3:30])([CH3:29])[CH2:13][C:14]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][CH:26]=[CH:27][C:20]=2[N:19]([CH2:32][C:33]2[CH:34]=[CH:35][C:36]([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=3[C:45]([F:46])([F:47])[F:48])=[CH:37][CH:38]=2)[C:18]1=[O:28])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 218366093-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamideHCID 222469904'-Bromomethyl-2-trifluoromethyl-1,1'-biphenyl

生成物 1

HCID 19766191HCID 19766191、化合物

実験手順

Prepared from 3-benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl ]-butanamide (Example 51, Step A) and 4'-bromomethyl-2-trifluoromethyl-1,1'-biphenyl by the procedure described in Example 1, Step K. 1H NMR (300 MHz,CDCl3): 1.37 (s,3H), 1.39 (s,3H), 1.73 (m,1H), 2.2-2.6 (m,5H), 4.50 (m,1H), 4.82 (d,15Hz,1H), 5.06 (s,2H), 5.29 (d,15Hz,1H), 5.65 (s,1H), 6.70 (d,7Hz,1H), 7.1-7.4 (m,14H), 7.44 (t,8Hz,1H), 7.52 (t,8Hz,1H), 7.71 (d,8Hz,1H). FAB-MS: calculated for C37H36F3N3O4 643; found 644 (M+H,55%).

出典と根拠

ORDレコード
ord-070db0ea0c5942d7898c5dcf21df1b8f
出典データセット
uspto-grants-1994_05
特許番号
US05310737

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