Benzyl Bromide → 7,8-Dihydro-2-(phenylmethoxy)-5(6H)-quinolinone

HRID 1033503ノート

反応式

HRID 1033503 の反応式
[O:1]=[C:2]1[CH2:11][CH2:10][CH2:9][C:8]2[NH:7][C:6](=[O:12])[CH:5]=[CH:4][C:3]1=2.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(=O)([O-])[O-].[Ag+2].C1(C)C=CC=CC=1>[O:1]=[C:2]1[CH2:11][CH2:10][CH2:9][C:8]2[N:7]=[C:6]([O:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:5]=[CH:4][C:3]1=2

参加物

5

反応物 2

HCID 7498Benzyl BromideHCID 2674502-Hydroxy-7,8-dihydro-5(6H)-quinolinone

生成物 1

HCID 104449777,8-Dihydro-2-(phenylmethoxy)-5(6H)-quinolinone収率 89%

試薬・触媒・溶媒 2

HCID 178418647HCID 178418647、化合物触媒HCID 1140Toluene溶媒

実験手順

A suspension of 5,6,7,8-tetrahydro-5-oxo-2(1H)-quinolinone (33.0 g), silver carbonate (35.0 g), benzyl bromide (44.4 g), and toluene (400 ml) was stirred at room temperature for 72 hrs. The mixture was filtered and the filtrate was concentrated. Trituration of the residue with petroleum ether gave 45.6 g (83%) of product.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-9a4cb8125e774473a9f8691548d992e6
出典データセット
uspto-grants-1994_05
特許番号
US05310914

反応ノート

読み込み中…