2-Pentynoic acid, methyl ester → HCID 178440058、化合物

HRID 1033605ノート

反応式

HRID 1033605 の反応式
[C:1]([O:7][CH3:8])(=[O:6])[C:2]#[C:3][CH2:4][CH3:5].[C:9](=[N:14]O)([NH2:13])[CH2:10][CH2:11][CH3:12]>C1(C)C(C)=CC=CC=1>[CH2:4]([C:3]1[N:13]=[C:9]([CH2:10][CH2:11][CH3:12])[NH:14][C:2]=1[C:1]([O:7][CH3:8])=[O:6])[CH3:5]

参加物

4

反応物 2

HCID 904702-Pentynoic acid, methyl esterHCID 2794811N-Hydroxybutyramidine

生成物 1

HCID 178440058HCID 178440058、化合物収率 27.9%

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

反応条件

温度
50 °C

実験手順

93 g of methyl pentynoate and 82 g butyramidoxime are mixed together without solvent and heated to 50° C for 24 hours. 400 mL xylene was added and water was azaeotropically removed for 6 hours. The reaction was then distilled (140° C. at 0.2 torr) to give 44 g product.

後処理

  1. customwater was azaeotropically removed for 6 hours
  2. distillationThe reaction was then distilled (140° C. at 0.2 torr)

出典と根拠

ORDレコード
ord-9f5701372eab455db5c3bc9937b31efa
出典データセット
uspto-grants-1994_05
特許番号
US05310929

反応ノート

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