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Hydrochloric Acid → 3'-Chloro-4'-octyloxy-4-biphenylcarboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Dichloramine-T | HCID 68056 | — |
| 反応物 | 4'-(Octyloxy)-[1,1'-biphenyl]-4-carboxylic acid | HCID 2802556 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3'-Chloro-4'-octyloxy-4-biphenylcarboxylic acid | HCID 14794181 | 128.2% |
反応手順
N,N-dichloro-p-toluenesulfonamide (hereinafter abbreviated to "dichloramine T") (7.5 g, 0.032 mol) was dissolved in acetic acid (100 ml), followed by adding to the solution, hydrochloric acid (0.4 ml), dropwise adding to the acetic acid solution of dichloramine T, a solution of 4'-octyloxy-4-biphenylcarboxylic acid (20 g, 0.063 mol) dissolved in acetic acid (100 ml), refluxing the mixture, allowing it to stand overnight, distilling off acetic acid and filtering off deposited crystals to obtain 3'-chloro-4'-octyloxy-4-biphenylcarboxylic acid (14.8 g) (C-Sc 146° C., Sc '-N' 224° C. and N'-I 232° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05312564 |
| 出典データセット | uspto-grants-1994_05 |
| ORD ID | ord-efebf27abd834d94a66ef657ccdc98b9 |
| 出典メモ | uspto-grants-1994_05 |