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Hydrochloric Acid → 3-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Dichloramine-T | HCID 68056 | — |
| 反応物 | Benzoic acid, 4-hydroxy-, 2-methylbutyl ester | HCID 13530949 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-Chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester | HCID 23041682 | 144.2% |
反応手順
On the other hand, dichloramine T (28.0 g, 0.12 mol) was dissolved in acetic acid (450 ml), and hydrochloric acid (1.5 ml) was added. The resulting solution was dropwise added to a solution of the above p-hydroxybenzoic acid 2-methyl-butyl ester (50 g, 0.24 mol) dissolved in acetic acid (450 ml), followed by refluxing the mixture, allowing to stand overnight, distilling off acetic acid and filtering off deposited crystals to obtain 3-chloro-4-hydroxy-benzoic acid 2-methyl-butyl ester (42 g) (b.p. 135°~138° C./4 mmHg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05312564 |
| 出典データセット | uspto-grants-1994_05 |
| ORD ID | ord-9628d6e533e344f2897cf7d0226e1cb9 |
| 出典メモ | uspto-grants-1994_05 |