1-(2-Pyridyl)piperazine → HCID 15233925、化合物

HRID 1033713ノート

反応式

HRID 1033713 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:12](=[O:13])[C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[NH:9][CH2:8][C:7]1=[O:18].[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>O1CCOCC1>[N:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:26][CH2:27][N:28]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[C:12](=[O:13])[C:11]3[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=3[NH:9][CH2:8][C:7]2=[O:18])[CH2:29][CH2:30]1

参加物

4

反応物 2

HCID 944591-(2-Pyridyl)piperazineHCID 19024285HCID 19024285、化合物

生成物 1

HCID 15233925HCID 15233925、化合物収率 97%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 70 mg of the compound of Example 14 dissolved in 10 ml of dioxane was added 0.105 ml (3 equivalents) of 1-(2-pyridyl)piperazine and the mixture heated under reflux for 8 hours. The reaction treatment and purification were conducted as in Example 17, to obtain 86.2 mg of the desired compound (yield 97%). The maleate was obtained by converting the product to maleate in a conventional manner, followed by recrystallization from methylene chloride-ether.

後処理

  1. temperaturethe mixture heated
  2. temperatureunder reflux for 8 hours
  3. customThe reaction treatment and purification

出典と根拠

ORDレコード
ord-9cd81ae382504dfa9223730889dfc534
出典データセット
uspto-grants-1994_05
特許番号
US05312625

反応ノート

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