HCID 86747869、化合物 → HCID 9974054、化合物

HRID 1033886ノート

反応式

HRID 1033886 の反応式
[CH2:1]([C:5]1[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[C:7](/[C:10](/[CH3:17])=[CH:11]/[C:12]([O:14]CC)=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]>C(OCC)(=O)C.CO>[CH2:1]([C:5]1[N:6]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[Cl:25])[C:7](/[C:10](/[CH3:17])=[CH:11]/[C:12]([OH:14])=[O:13])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

参加物

3

反応物 1

HCID 86747869HCID 86747869、化合物

生成物 1

HCID 9974054HCID 9974054、化合物

試薬・触媒・溶媒 1

HCID 21584119Ethylacetate methanol溶媒

実験手順

The title compound was prepared according to Example 1(v) by using ethyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-3-methyl-2-propenoate in place of ethyl-(E)-3-[2-n-butyl-1-{(2-chlorgphenyl)methyl}-1H-imidazol-5-yl]-2-methyl-2-propenoate. The title compound was a white solid, and was converted to the hydrochloride salt to give 82 mg (41%); mp 198°-199.5° C. (from ethyl acetate/methanol).

後処理

  1. customThe title compound was prepared
  2. customto give 82 mg (41%)

出典と根拠

ORDレコード
ord-7903f81c2fa1499096d8c0904150d87b
出典データセット
uspto-grants-1994_05
特許番号
US05312828

反応ノート

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