4-Methoxybenzyl alcohol → p-Methoxybenzyl acrylate
反応式
C(C1N(CC2C=CC=CC=2Cl)[C:7](/C=C(\CC2C=CC=CC=2)/C(O)=O)=[C:8]([CH2:10][OH:11])N=1)CCC.[CH3:32][O:33][C:34]1[CH:41]=[CH:40][C:37]([CH2:38][OH:39])=[CH:36][CH:35]=1>>[C:10]([O:39][CH2:38][C:37]1[CH:40]=[CH:41][C:34]([O:33][CH3:32])=[CH:35][CH:36]=1)(=[O:11])[CH:8]=[CH2:7]参加物
3
実験手順
(E)-3-[2-n-Butyl-1-[(2-chlorophenyl)methyl]-4-hydroxymethyl-1H-imidazol-5-yl]-2-benzyl-2-propenoic acid, prepared as in Example 28, is esterified with p-methoxy-benzyl alcohol to give the p-methoxybenzyl propenoate. The 4-hydroxymethyl group is oxidized using Jones reagent in acetone and the ester is hydrolized using 10% sodium hydroxide to give the title compound.
出典と根拠
- ORDレコード
- ord-b7e90e03d6104bf2b332356eb5d5c5b1
- 出典データセット
- uspto-grants-1994_05
- 特許番号
- US05312828
反応ノート
読み込み中…