2-[(1-Acetyl-2-indolyl)carbonylamino]-4-(2,4-dimethoxyphenyl)-5-ethoxycarbonylmethylthiazole → 2-[(2-Indolyl)carbonylamino]-4-(2,4-dimethoxyphenyl)-5-carboxymethylthiazol

HRID 1034189ノート

反応式

HRID 1034189 の反応式
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5]1[C:13]([NH:15][C:16]1[S:17][C:18]([CH2:31][C:32]([O:34]CC)=[O:33])=[C:19]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=2[O:29][CH3:30])[N:20]=1)=[O:14])(=O)C>C(O)C>[NH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[C:5]1[C:13]([NH:15][C:16]1[S:17][C:18]([CH2:31][C:32]([OH:34])=[O:33])=[C:19]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=2[O:29][CH3:30])[N:20]=1)=[O:14]

参加物

3

反応物 1

HCID 189465652-[(1-Acetyl-2-indolyl)carbonylamino]-4-(2,4-dimethoxyphenyl)-5-ethoxycarbonylmethylthiazole

生成物 1

HCID 189465792-[(2-Indolyl)carbonylamino]-4-(2,4-dimethoxyphenyl)-5-carboxymethylthiazol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

0.5 g of 2-[(1-acetyl-2-indolyl)carbonylamino]-4-(2,4-dimethoxyphenyl)-5-ethoxycarbonylmethylthiazole, prepared above according to Example 10, is dissolved in 10 ml of 950 ethanol and then 1.5 ml of 2N NAOH are added. The reaction mixture is stirred overnight at room temperature and then concentrated under vacuum. The residue is taken up in a buffer solution, pH=2, a precipitate is separated by filtration, washed with water, filtered and then rinsed with ether.

後処理

  1. addition1.5 ml of 2N NAOH are added
  2. concentrationconcentrated under vacuum
  3. customa precipitate is separated by filtration
  4. washwashed with water
  5. filtrationfiltered
  6. washrinsed with ether

出典と根拠

ORDレコード
ord-9dc1469100b142ad8d3fb2f72dc569fa
出典データセット
uspto-grants-1994_05
特許番号
US05314889

反応ノート

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