Diethyl Ether → HCID 57153373、化合物

HRID 1034253ノート

反応式

HRID 1034253 の反応式
[C:1]1([N:7]2[CH2:11][CH2:10][C:9](=O)[C:8]2=[O:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][N:15]1[CH2:19][CH2:18][CH2:17][CH:16]1[CH2:20][O:21][CH3:22].CCOCC>C1C=CC=CC=1>[CH3:22][O:21][CH2:20][CH:16]1[CH2:17][CH2:18][CH2:19][N:15]1[N:14]=[C:9]1[CH2:10][CH2:11][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[C:8]1=[O:13]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 1436632-(Methoxymethyl)pyrrolidin-1-amineHCID 190235711-Phenylpyrrolidine-2,3-dione

生成物 1

HCID 57153373HCID 57153373、化合物

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

A solution of the product of Example 61 and chiral 1-amino-2-methoxymethylpyrrolidine (SAMP or RAMP; 1 equiv) in benzene is refluxed under Dean-Stark conditions for 20 h. After cooling, Et2O is added and the mixture is washed with water. The organic layer is dried (MgO4) and evaporated to give a residue which is chromatographed on silica gel to give the title compound.

後処理

  1. temperatureAfter cooling
  2. washthe mixture is washed with water
  3. customThe organic layer is dried (MgO4)
  4. customevaporated
  5. customto give a residue which
  6. customis chromatographed on silica gel

出典と根拠

ORDレコード
ord-7cd4eb49a4a64bc196af6fa9a1c1c900
出典データセット
uspto-grants-1994_05
特許番号
US05314886

反応ノート

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