Hydrochloric Acid → (3-Methylpyrrolidin-3-yl)methanol hydrochloride

HRID 1035256ノート

反応式

HRID 1035256 の反応式
[OH:1][CH2:2][C:3]1([CH3:15])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.CO.[ClH:18]>>[ClH:18].[CH3:15][C:3]1([CH2:2][OH:1])[CH2:7][CH2:6][NH:5][CH2:4]1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 597084561-Boc-3-methylpyrrolidine-3-methanol

生成物 1

HCID 66653455(3-Methylpyrrolidin-3-yl)methanol hydrochloride

実験手順

tert-butyl 3-(hydroxymethyl)-3-methylpyrrolidine-1-carboxylate (0.31 g, 1.44 mmol, see WO 2009132986) was dissolved in HCl in methanol (1.25M, 3.5 mL, 4.32 mmol). The reaction mixture was stirred at RT overnight and then the mixture was evaporated. Ethanol was added and the mixture was again evaporated to afford 243 mg. The crude product was used in the next step without further purification.

後処理

  1. customthe mixture was evaporated
  2. additionEthanol was added
  3. customthe mixture was again evaporated
  4. customto afford 243 mg
  5. customThe crude product was used in the next step without further purification

出典と根拠

ORDレコード
ord-6b9f9abe7b2e4461acffaa9c909ff603
出典データセット
uspto-grants-2013_10
特許番号
US08546375B2

反応ノート

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