Ammonia → HCID 59548516、化合物

HRID 1035300ノート

反応式

HRID 1035300 の反応式
C([O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:17]#[N:18])C.N>CO.[Ni]>[CH:16]1[C:11]2[C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4](=[O:3])[NH:18][CH2:17][C:12]=2[CH:13]=[N:14][CH:15]=1

参加物

5

反応物 2

HCID 222AmmoniaHCID 66769548HCID 66769548、化合物

生成物 1

HCID 59548516HCID 59548516、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A mixture of Example 180C (29.4 g, 0.117 mol) and Raney®-nickel (30 g) in 2 L of methanol saturated with NH3 was stirred under H2 (50 psi) at 50° C. for 24 hours. After cooling and removal of the catalyst, the mixture was concentrated under reduced pressure to obtain the title compound which was used without further purification.

後処理

  1. temperatureAfter cooling
  2. customremoval of the catalyst
  3. concentrationthe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-5066493f0c9045eb9711fc2072dcd3ae
出典データセット
uspto-grants-2013_10
特許番号
US08546377B2

反応ノート

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