Hydrochloride methanol → cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

HRID 1035303ノート

反応式

HRID 1035303 の反応式
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]2[CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][C@H:5]2[CH2:4][NH:3]1.Cl.CO>C(OCC)C>[CH2:13]1[C@H:6]2[C@H:5]([CH2:4][NH:3][C:2](=[O:1])[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=32)[CH2:16][NH:15][CH2:14]1

参加物

4

反応物 2

HCID 21893726Hydrochloride methanolHCID 67249978Tert-butyl cis-7-oxo-1,2,4,4a,5,6,7,11b-octahydro-3h-pyrido[3,4-d][2]benzazepine-3-carboxylate

生成物 1

HCID 49763200cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a suspension of Example 180G in 400 mL of diethyl ether was added 80 mL of HCl/methanol (5/V) at 25° C. The mixture was stirred overnight. The solid formed was collected and dried to obtain the title compound as the hydrochloride salt.

後処理

  1. customThe solid formed
  2. customwas collected
  3. customdried

出典と根拠

ORDレコード
ord-5286a10581514c068c51fe5b348b28b2
出典データセット
uspto-grants-2013_10
特許番号
US08546377B2

反応ノート

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