化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | N-Boc-4,4-difluoro-L-proline methyl ester | HCID 11129200 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate | HCID 45082563 | — |
反応手順
(S)-1-tert-butyl 2-methyl 4,4-difluoropyrrolidine-1,2-dicarboxylate (0.472 g) in CH2Cl2 (1 mL) was treated with trifluoroacetic acid (1.4 mL), stirred at ambient temperature for 4 hours, and concentrated. The product was free-based using a MEGA BE-SCX column with 1:1 CH2Cl2/methanol as eluent for the trifluoroacetic acid. The product was released from the column with 5% (7 M ammonia in methanol) in CH2Cl2 as eluent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08546399B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-b635a8837e8847eca488274e5fbc6221 |
| 出典メモ | uspto-grants-2013_10 |