Water → HCID 67126688、化合物

HRID 1036046ノート

反応式

HRID 1036046 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]1([F:24])[CH2:15][CH2:14][C:13]2(OC3C=CC=CC=3[O:16]2)[CH2:12][CH2:11]1.C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.O>CC(C)=O.ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]1([F:24])[CH2:15][CH2:14][C:13](=[O:16])[CH2:12][CH2:11]1

参加物

6

反応物 3

HCID 962WaterHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 671269175-Chloro-6-((4'-fluoro spiro[benzo[d][1,3]dioxole-2,1'-cyclohexane]-4'-yl)methoxy)pyridine-3-sulfonamide

生成物 1

HCID 67126688HCID 67126688、化合物

試薬・触媒・溶媒 2

HCID 180Acetone溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
100 °C

実験手順

To a solution of EXAMPLE 350D (1.6 g) and pyridinium p-toluenesulfonate (1.2 g) in acetone (10 mL) was added water (2 mL) and the mixture was stirred under microwave irradiation at 100° C. for 10 minutes. The mixture was diluted with dichloromethane (300 mL) and washed with aqueous NaHCO3, water, brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.

後処理

  1. washwashed with aqueous NaHCO3, water, brine
  2. dry with materialdried over Na2SO4
  3. filtrationFiltration and evaporation of the solvent

出典と根拠

ORDレコード
ord-6950975f8ff245cbb877d439ca237215
出典データセット
uspto-grants-2013_10
特許番号
US08546399B2

反応ノート

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