Potassium Cyanide → 4-Bromo-3-(trifluoromethyl)phenylacetonitrile

HRID 1036178ノート

反応式

HRID 1036178 の反応式
CS(O[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[C:9]([C:14]([F:17])([F:16])[F:15])[CH:8]=1)(=O)=O.[C-:18]#[N:19].[K+]>C(O)C.O>[Br:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][C:18]#[N:19])=[CH:8][C:9]=1[C:14]([F:17])([F:16])[F:15]

参加物

5

反応物 2

HCID 9032Potassium CyanideHCID 866579514-Bromo-3-(trifluoromethyl)benzyl methanesulfonate

生成物 1

HCID 459337024-Bromo-3-(trifluoromethyl)phenylacetonitrile

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of 4-bromo-3-(trifluoromethyl)benzyl methanesulfonate 46-4 (1.295 g, 3.75 mmol) in ethanol (10 mL) was added a solution of potassium cyanide (364 mg, 5.6 mmol) in water (2 mL). The mixture was refluxed for 2 hours. After the mixture was cooled down to the room temperature, all the solvents were evaporated and the residue was redissolved in dichloromethane (50 mL), washed with water and brine, dried over Na2SO4, and concentrated to dryness to give 2-(4-bromo-3-(trifluoromethyl)phenyl)acetonitrile 46-5 as dark brown oil, which was used for next step directly. MS m/z 264.1 (M+1)

後処理

  1. temperatureThe mixture was refluxed for 2 hours
  2. customwere evaporated
  3. dissolutionthe residue was redissolved in dichloromethane (50 mL)
  4. washwashed with water and brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-02a6cc413c4b492da6c8ad58dd6b278c
出典データセット
uspto-grants-2013_10
特許番号
US08546396B2

反応ノート

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